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M9650280.TXT
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1996-03-09
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Document 0280
DOCN M9650280
TI Changes in T-cell subpopulations in mice during prolonged experimental
secondary infection with Echinococcus granulosus.
DT 9605
AU Rueda MC; Osuna A; De Rycke PH; Janssen D; Laboratorio de Analisis,
Hospital Torrecardenas, Almeria,; Spain.
SO Biosci Rep. 1995 Aug;15(4):201-8. Unique Identifier : AIDSLINE
MED/96126621
AB Balb/c mice were infected intraperitoneally with protoscoleces of
Echinococcus granulosus. After 15 months of infection, and by means of
flow cytometry, the expression of T-cell markers CD3, CD4, and CD8 on T
cells from peripheral blood, spleen, and thymus was analyzed and
compared with that of age-matched controls. Infected mice had higher
percentages of CD3+, and CD4+ cells in peripheral blood, and higher
percentages of CD8+ cells in the spleen, when compared with control
mice. CD4+ and CD8+ cells in peripheral blood and CD8+ cells in thymus
also showed higher percentages of expression of interleukin-2 receptor.
The results infer a role for interleukin-2 in experimental secondary
echinococcosis.
DE Animal Antigens, CD3/ANALYSIS CD4-CD8 Ratio CD4-Positive
T-Lymphocytes/PARASITOLOGY CD8-Positive T-Lymphocytes/PARASITOLOGY
Echinococcosis/BLOOD/*IMMUNOLOGY Female Flow Cytometry Mice Mice,
Inbred BALB C Receptors, Interleukin-2/ANALYSIS
Spleen/CYTOLOGY/IMMUNOLOGY Support, Non-U.S. Gov't T-Lymphocyte
Subsets/CHEMISTRY/METABOLISM/*PARASITOLOGY Thymus
Gland/CYTOLOGY/IMMUNOLOGY Time Factors JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).